U.S. Patent 7756583 was awarded to Ardian, Inc. on 2010-07-13 and describes a “Methods and apparatus for intravascularly-induced neuromodulation.” This patent has been cited 262 times by other U.S. patents which places it in the top 500 cited patents since 2010 according to our law firm research, and makes it of the most innovative medical technology patents in the field of instruments. The abstract states:

Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient’s vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient’s vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient’s vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function. Link: U.S. Patent 7756583

This patent was originally filed on 2005-11-04 which gives it a processing time of 1712 days, compared to an average processing time of 1742 in the field. Ardian, Inc. has 29 total patents. The first named inventor is Denise Demarais of Los Gatos, CA. The primary examiner was Mark W Bockelman.

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